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Native GLP-1 is rapidly degraded by dipeptidyl peptidase-IV (DPP-IV) in the blood stream

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These peptides regulate energy homeostasis by acting directly on target tissues as hormones or by activating intrinsic and extrinsic neurons in a paracrine manner 9,10

Sandgren KJ, Truong NR, Smith JB, Bertram K, Cunningham AL

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