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Cancer cells in tumors with IDH1 or IDH2 mutations show oncogenic activity by converting glutamine-derived -KG to 2-hydroxyglutarate (2-HG), which competitively inhibits -KG-dependent histone and DNA modification enzymes 27

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By 2050, almost 60% of adults over 25 are expected to be overweight or obese, up from 29% in 1990, with the biggest growth in sub-Saharan Africa, according to a study in The Lancet External link

Enhanced Stability : Modifications to its structure improve its efficacy and half-life, allowing for once-weekly dosing ( 6 )

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