Scoon GS, Hopkins WG, Mayhew S, Cotter JD
Clinical trial data shows tirzepatide produces 2-3 times more weight loss than liraglutide
A lack of B12 has been observed in some cases of depression, suggesting that adequate levels may reduce the risk of severe mood disorders
Patients with pre-existing gastroparesis, severe reflux, or a history of gastric surgery should consult their provider before starting GLP-1 therapy, as delayed emptying may complicate existing conditions
SARS-CoV-2 infection of Calu-3 cells caused a strong induction of the antiviral interferon-stimulated gene (ISG) signature, including several antiviral effectors, such as cGAS, Mx1, IFIT, IFIH, IFI16, IFI44, OAS, and ISG15, pathways of vesicular transport, tight junctions (KIF5A/B/C, OSBPL2, CLTCL1, and ARHGAP17) and ubiquitin modification (UBE2L3/5), as well as reprogramming of host metabolism, transcription and translation
Weight loss is minimal, often 1-2 pounds over the first month, primarily from reduced food intake rather than dramatic appetite changes
