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For some users, nausea remains problematic throughout treatment, requiring dose adjustment or discontinuation

Some antidepressants can affect appetite and weight directlyfor example, certain SSRIs and mirtazapine are known to increase appetite or slow metabolism

The study also found major adverse cardiovascular eventslike heart attack or failureoccurred less frequently than anticipated. Retatrutide is considered likely the most powerful weight loss drug yet, as it targets multiple hormonesGLP-1, GIP and glucagonthat impact appetite and metabolism, whereas other drugs currently on the market target one or two of those hormones

Call to Action: Ready to take control of your weight and health

GLP-1 Dose Calculator, Convert Your mg Dose to Syringe Units Enter your prescribed dose in mg and your vial concentration, and get the exact number of units to draw on a standard U-100 insulin syringe, plus the typical semaglutide and tirzepatide titration schedule

Tirzepatide is one option that providers may evaluate based on health history, goals, and overall suitability