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Chemotherapeutic regimens, such as anthracycline-based combinations with ifosfamide, are associated with significant toxicity and rapid development of resistance, offering limited survival advantage ( Notably, in this case, subtotal resection was performed due to dense adhesion between the tumor and spinal nerve root

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Schnemann HJ, Higgins JP, Vist GE, et al

It's one of the fundamental mechanisms of aging