As alluded to above, the rationale for combining GLP-1R agonism with either GIPR agonism or antagonism is, however, still debated, and how the GIPR agonistic properties of tirzepatide contribute to body-weight loss remains unclear [19]
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My belief is as we get better at improving the overall efficiencies of cellular mitochondrial function with continued advances in GLP1RAs we will be humbled by the continued beneficial signaling pathways that improve overall health, he said
Many people at stable maintenance doses report minimal or no side effects after the initial adjustment period
Tirzepatide, an FDA-approved dual GIP/GLP-1 receptor agonist for type 2 diabetes and obesity, works through incretin-based glucose regulation and appetite suppression
However, the combination requires careful consideration and monitoring by your healthcare team