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Lixisenatide administered to pregnant rats and rabbits during organogenesis was associated with visceral closure and skeletal defects at systemic exposures that decreased maternal food intake and weight gain during gestation, and that are 1-time and 6-times higher than the 20 mcg/day highest clinical dose, respectively, based on plasma AUC [see Data]

The design also ensured that the results were applied to controlled experimental settings and real-world athletic contexts, particularly for high-intensity and endurance athletes

Biological fate of ingested lipid-based nanoparticles: current understanding and future directions

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