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Clinical Highlights of Retatrutide Study: 48-week, double-blind, placebo-controlled Phase 2 trial Results: ~22.8% weight loss (8 mg dose), ~28.2% weight loss (12 mg dose) ~0.9% HbA1c reduction Significant improvements in cardiometabolic risk factors Safety & Tolerability Most common side effects: nausea, vomiting, diarrhea, abdominal discomfort, constipation typically mild to moderate and dose-dependent

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More than 60 years have passed since the first generation of SUs (tolbutamide, tolazamide, chlorpropamide, and acetohexamide) were successfully launched into mainstream clinical practice as oral glucose-lowering agents for the management of type 2 diabetes (T2D) [14]

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Transcription factor EB enhances autophagy and ameliorates palmitate-induced insulin resistance at least partly via upregulating AMPK activity in skeletal muscle cells

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