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Whilst GLP-1 receptor agonists have been available for over a decade, the addition of GIP receptor agonism represents a novel therapeutic approach that appears to enhance metabolic benefits beyond those achieved with GLP-1 agonism alone

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For simulation of typical profiles at steady state, mean parameter values are shown in Table 2 for the subset of the clinical pharmacology population who used the recommended dosing conditions for oral semaglutide ( N = 209 healthy subjects, N = 55 subjects with T2D)

Oliver RL, Davis JR, White A

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Clinicians should exercise caution in patients with a history of pancreatitis or gastroparesis, inflammatory bowel disease, other gut motility disorders, medullary thyroid carcinoma, or Multiple Endocrine Neoplasia syndrome type 2, and pause therapy when clinically indicated, such as before anesthesia