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"Rapid fat loss in patients taking semaglutide or similar GLP-1 receptor agonists can make wrinkles more prominent and cause skin sagging in areas like the temples, cheeks, tear troughs, jawline, marionette lines and nasolabial folds, disrupting facial balance

Frequently Asked Questions How much weight do most people regain after stopping semaglutide

Garcia D, Shaw RJ

Some healthcare professionals may recommend the combination because of theoretical considerations

Weight regain or reduced appetite suppression after a previously effective phase, with no other obvious cause, can sometimes point to a compromised pen

Alcohol Use (2025)