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Beyond classical process impurities, developers must manage sequence-level variants, isomerisation, epimerisation and side-chain modifications that may occur at low levels yet still influence potency, stability or immunogenicity

Levi Garraway, Roches Chief Medical Officer and Head of Global Product Development

Different patterns of plasma medium and long chain acylcarnitine alterations usually occurred with other biomarkers of mitochondrial energy metabolism (Figure 5, groups 2, 5, and 7)

Selective expression of neuronal cell adhesion molecule (NCAM)-180 in optic nerve head astrocytes exposed to elevated hydrostatic pressure in vitro

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