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PLoS ONE 19 , e0308533 (2024)

doi: 10.1530/eje.0.1380524 146 AriasASchanderJABarianiMVCorreaFDomnguez RubioAPCellaMet al

But glutathione amino acid precursors mitigated this effect, making it more useful than standard antioxidants to protect skin against environmental pollutants

The SELECT trial established cardiovascular risk reduction in overweight adults without diabetes, while the STEP HFpEF program showed symptomatic improvement in heart failure with preserved ejection fraction [2]

The present study emulated a target trial to avoid immortal time and selection bias, chose a second-line glucose-lowering therapy as an active comparator to reduce confounding by indication, used an outcome definition based only on primary care records to minimize detection bias due to differential hospitalizations, and implemented a lag time to mitigate bias due to reverse causality

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