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**Who should still consider it:** Patients who prefer daily rather than weekly dosing (a small minority), those who respond poorly to newer agents, or situations where cost and insurance coverage strongly favor Saxenda

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Following MTX injection (in physiological saline, 20 mg/kg, single dose), either saline (MTX group, n 8) or WPC (2 g/kg, oral gavage, MTX + WPC group

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The most common side effects are gastrointestinal in nature and typically diminish over time as the body adjusts to the medication

food noise may disappear