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Moreover, HSP-70 enhances tumorigenicity and metastasis in murine models and promotes the expression of stemness markers (Nanog, Oct3/4, and SOX2) in stiff hydrogels by increasing the activity of the transcription factor signal transducer and activator of transcription 3 (STAT3) [119]
We have preliminary observations in support (Tsutsui et al., 2019), and this could be expanded with a more detailed dissection of the precise transmissible species, target elements (for instance, is the myelinating unit most vulnerable?), and mechanisms of transmission and spread