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If the answer affects treatment, cost, pharmacy choice, or dosing, bring the specifics to a licensed clinician before acting
The increase in circulating homocysteine related to impaired homocysteine metabolism may favor the accretion of a pro-oxidant environment by increasing concentrations of free radicals, by maintaining metal ions in their reduced state suitable for the Fenton reaction, and by changing the redox status of intra- and extracellular thiol groups and, hence, the intracellular redox potential (Mansoor et al, 1993a
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Mortality associated with metformin versus sulfonylurea initiation: A cohort study of veterans with diabetes and chronic kidney disease
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