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Any disagreements were resolved through consultation with a third reviewer (M.K.), who provided a final assessment to ensure the accuracy and completeness of the selected studies

In chronic kidney disease (CKD), reduced renal clearance leads to TMAO accumulation, and observational studies consistently report higher circulating TMAO with lower eGFR

Ulmasov T, Ohmiya A, Hagen G, Guilfoyle T 1995 The soybean GH2/4 gene that encodes a glutathione S-transferase has a promoter that is activated by a wide range of chemical agents

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For instance, a dandelion-derived polysaccharide was shown to inhibit the PI3K/Akt pathway, downregulating HIF-1 and VEGF expression, and thereby suppressing tumor angiogenesis (138)

That might mean talking to a dietitian, therapist, or doctor, or using tools that guide you toward healthier habits every day