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New delivery methods like GLP-1 patches and oral versus injectable formulations are also changing how these medications reach patients, which could indirectly affect eligibility standards as access models evolve

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Pembrolizumab (Keytruda) and nivolumab (Opdivo), both approved by the FDA in 2014, have become frontline medication for metastatic melanoma

Both tirzepatide and semaglutide mimic the hormone GLP-1, but tirzepatide also mimics another hormone, glucose-dependent insulinotropic polypeptide (GIP), and this may further contribute to weight loss

Fever above 101.3F (38.5C): Fever with diarrhea suggests infection requiring treatment