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Pharmacokinetics: Data indicate a linear pharmacokinetic profile with a short half-life ( 1000mcg/day) have been anecdotally associated with increased chances of headaches, fatigue, or water retention, and may lead to diminishing returns, suggesting a bell-shaped dose-response curve

doi:10.1126/science.abb7542

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It is not FDA-approved for cosmetic or performance use and is banned in sport