Obesity (Silver Spring, Md.), 23 (12), 23192320
Comparable to other peptides linked to fatty acids (e.g., the insulins detemir and degludec, the GLP-1RA liraglutide and semaglutide), the fatty acid side chain allows binding to albumin after subcutaneous injection, slows enzymatic degradation and prolongs biological half-life (5760)
The toxin resembled glucagon, a hormone that raises blood sugar, so, scientists named it glucagon-like-peptide 1, or GLP-1. In the early 2000s, we got our first medical breakthrough with GLP-1, a drug called exenatide (Byetta) approved for the treatment of type 2 diabetes
At the same time, GLP-1s tell the body to slow glucagon release, which raises blood sugar levels
Frontline providers also need better training in addressing excess weight among kids, says Cooper
Sources: Neeland, Ian J., et al