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Drug interactions and metabolism Weight loss associated with GLP-1R use may alter drug metabolism of weight-based medications (e.g., levothyroxine, warfarin )

FDA Approval Timeline As of mid-2025, Retatrutide is: Still under investigation in phase 3 clinical trials Expected to complete primary trials by late 2025 Anticipated to receive FDA approval in 2026 Until then, it is available only for research purposes , and should not be used outside of controlled clinical settings without professional supervision

And that's the best comparator

These discussions often center on everyday experiences with GLP-1 medications, including how dosing choices affect comfort, cost, and consistency

And I think well get to a point where we do maybe grandfather people that are on them now

Patients were also required to have at least one outpatient encounter within the four years prior the prescription