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Some vendor and storage guides mention wider windows such as 3-6 weeks, but that does not mean every vial should be pushed to the longest possible date

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Furthermore, women with endometriosis have a marked increase in TNF- concentration in the granulosa cells [103, 104, 105, 106], which leads to the reduction in the size of the inner cell mass and in the proliferation of the trophoectoderm in the blastocyst, it was observed that the integration of the culture medium with LC allowed to neutralize the antiproliferative effect of TNF- and to limit DNA damage during embryo development [93]