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Newer therapies such as GLP-1 receptor agonists and dual GIP/GLP-1 agents are prohibitively expensive, raising concerns about long-term sustainability and limiting patient access

Furthermore, the human subject trials varied in length and dose, which makes it hard to conclude that GLP-1 use prevents muscle loss while losing fat at this time, and we dont know if exercise was a variable controlled for

Some experience persistent mild dryness throughout treatment

Blood sugar fluctuations contribute significantly, as the medication can cause glucose levels to drop 20-30 mg/dL below baseline, triggering compensatory headache responses

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J., DeMartini, J