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PMID: 40813933 SSRN2025 Jan 14

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For most patients, the first dose is administered in the week preceding further therapy, with follow-ups every few weeks to help alleviate symptoms and support better health outcomes

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Four -ketoacid dehydrogenase complexes ( Figure 4 ), including: (i) the pyruvate dehydrogenase complex that catalyzes the conversion of pyruvate to acetyl-coenzyme A (CoA), an important substrate for energy production via the citric acid cycle