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The mechanism of action includes several key effects: they stimulate insulin secretion from pancreatic beta cells in a glucose-dependent manner, suppress glucagon release (which reduces hepatic glucose production), slow gastric emptying, and act on appetite centres in the brain to promote satiety and reduce food intake

The solubility of glibenclamide (glibenclamide), metformin, and sitagliptin was evaluated in triplicate in different pH using a water bath shaker at 37C using the shake- flask technique

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