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An in vitro study indicates that agomelatine can suppress the upregulation of AT1R expression in HUVECs and the human monocytic leukemia cell line THP-1 cells, and reduce the adhesion of monocytes to ECs, a process involved in the early stages of atherosclerosis

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While some research supports the idea that glutathione can reduce melanin and promote a lighter skin tone, large-scale studies are still lacking, and most evidence remains anecdotal

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