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Semaglutide reduces appetite as part of its weight loss effects, while Vyvanse often decreases appetite as a side effect

Discontinuing GLP-1 therapy does not appear to cause rapid weight rebound in all patients, particularly if lifestyle changes and improved metabolic function persist post-therapy

2) Nitric oxide (NO) generated by nitric oxide synthase (NOS) disrupts IL-2 signaling via inhibition of JAK-STAT, ERK, and AKT phosphorylation, destabilizing IL-2 and inducing T-cell apoptosis (188191)

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History of pancreatitis and severe gastrointestinal disease (such as severe gastroparesis) are important precautions, though not absolute contraindications

Association between constipation and colorectal cancer: systematic review and meta-analysis of observational studies