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In diet-induced obese mice (16 weeks HFD), subcutaneous 5-Amino-1MQ treatment for 11 days (20 mg/kg/injection, three injections daily) produced significantly reduced body weights, white adipose tissue masses, and adipocyte cell sizes compared to vehicle controls

These results indicate that subchronic ISF, possibly via periodical gastrointestinal distension, ameliorates arrhythmic overeating and obesity via GLP-1 release and activation of capsaicin-sensitive sensory nerves including vagal afferents

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Proc Natl Acad Sci USA 81:50075011 Migoya E, Miller J, Luo W-L et al (2010) Sitagliptin and metformin increase active GLP-1 by complementary mechanisms in treatment-nave patients with type 2 diabetes