on the supposed aggravation of COVID-19 ( more topical than ever ( The French Ministry of Health Olivier Veran embracing Micallefs hypothesis, warned the public to avoid NSAIDs like ibuprofen in case of SARS-CoV-2 infection ( On the other hand, the warning was immediately questioned (Rothuizen et al., 2020) and few months later a study on the association between routine use of NSAIDs and outcomes in hospitalized COVID-19 patients drawn completely different conclusions ( Indeed, a closer view to NSAIDs pharmacodynamics might lead to opposite conclusions on their therapeutic value in SARS-CoV-2 infection
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