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Retatrutides glucagon activity is one reason researchers think it may drive deeper fat loss for some people than single- or dual-pathway medicines

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GLP-1s may not influence Lp(a), but elevated levels indicate the need for intervention

JX is the guarantor of this work and had full access to all the data in the study and also takes responsibility for the integrity of the data

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However, in line with the specificity of CPA, the C-terminal residues of the L585I, L585M, and L585V variants were cleaved in vitro upon exposure to the enzyme for 5 hours at 37 C, as confirmed by liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis of the C-terminal peptides (Supplementary Table 1)