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Among those who did not adhere to their initial treatment within the 1year followup period, 90.5% of metformin initiators and 94.2% of GLP1RA initiators did not start another glucoselowering therapy afterward

Endocrine clinical pharmacist Diana Isaacs, PharmD, explains how both work

Both medications help with weight loss, but they work in different ways and have different benefits

A baseline DXA scan before or soon after starting GLP-1 therapy is strongly recommended, especially for post-menopausal women, adults over 50, and anyone with known risk factors for osteoporosis

Adding glucagon agonism to GLP-1/GIP would seem counterproductive glucagon normally raises blood glucose, which works against the insulin-promoting effects