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Dosage: 200-500 mcg, 1-2 times daily via subcutaneous injection or daily oral capsules

Exposure to TMAO decreases pyruvate metabolism ( via impaired substrate flux through pyruvate dehydrogenase), impairs -oxidation, and affects energy metabolism in cardiac muscle fibers, leading to the development of HF (Makrecka-Kuka et al., 2017)

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& Bottomley, J

There are four major dopaminergic pathways, the mesolimbic and the mesocortical (important for reward-related cognition and executive functions [212]), the nigrostriatal (known for its role in motor function [213]) and the tuberoinfundibular pathway (for the regulation of prolactin secretion [214])