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J Am Coll Cardiol 68:15751589

The condition was first described in 1940 as a clinical syndrome affecting women, marked by subcutaneous deposition of fat in the buttocks and lower extremities, and edema unresponsive to typical weight loss interventions.1 Despite its early identification, lipedema remained largely underrecognized for decades and was frequently misdiagnosed as obesity, lymphedema, venous insufficiency, or even cellulite

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