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Small human studies support the biological plausibility of both approaches, but there are no robust head-to-head clinical trials proving that one produces better health outcomes than the other

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When it comes to glutathione dose per day, clinical studies suggest that a glutathione dosage per day between 500 mg to 1000 mg is considered both safe and effective for skin brightening and antioxidant support

[DOI] [PMC free article] [PubMed] [Google Scholar] Kontur PJ, al-Tikriti M, Innis RB, Roth RH (1994) Postmortem stability of monoamines, their metabolites, and receptor binding in rat brain regions

PMID 858356

But it can be hard to tell if your investment is paying off based on feeling alone