Research has shown that women who cut more than 300 calories per day can experience menstrual disturbances, amenorrhea, lower metabolism, higher cortisol, and lower hormone levels, she wrote in a recent blog post on her website
Sipos B, Sperveslage J, Anlauf M, et al
Silva FO, Carvalho MS, Mendona R, Macedo WA, Balzuweit K, Reiss P, et al
doi: 10.1523/JNEUROSCI.5855-12.2013 104 KnightR.CallewaertC.MarotzC.HydeE
Tesamorelin's GHRH mechanism is tissue-specific to the pituitary
Despite the presence of these cofactors in both reviews, tirzepatide showed a significant weight loss efficacy with the MD ranging from 6.31 to 9.36 kg compared to placebo and 1.68 to 7.16 compared to GLP-1 RAs in Karagiannis et al.'s study and 7.0 to 8.6 kg in Bhagavathula et al.'s study