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SHK, as an inhibitor of uridine 5-diphosphateglucuronosyltransferase, exerts toxic effects on liver tissues ( in vitro study demonstrated that shikonin has potent cytotoxicity against 15 types of cancer cells through mitochondrial dysfunction and can induce apoptosis

Effects of pycnogenol on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo-controlled, cross-over study

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Other frequently reported side effects included fatigue (36.9%), headache (30.3%), and dizziness (25.9%) (Table 2)

2019 May;41(5):420-427

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