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The combined effect produces stronger results than single-receptor medications in clinical studies

Carnitine Acyltransferase II (CPT-II): Inside the mitochondrial matrix, CPT-II transfers the fatty acyl group back to CoA, regenerating fatty acyl-CoA and releasing free L-carnitine

First, remember that it happens

The most frequent side effects reported with LY3298176 were gastrointestinal (vomiting, nausea, decreased appetite, diarrhoea, and abdominal distension) in both HS and patients with T2DM

While the absolute risk remains relatively low, it is important for both patients and healthcare professionals to be aware of this potential complication