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In a healthy cell at rest, this ratio is strictly maintained at greater than 100:1

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In the early 90s, two genes encoding two 5 -reductase isozymes were eventually identified, and named steroid 5 -reductase type 1 (gene symbol: SRD5A1 ) and steroid 5 -reductase type 2 (gene symbol: SRD5A2 ) 11 14