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Melatonin improves local blood circulation and edema, and maintained the stability of the blood spinal cord barrier Studies have shown a reduction in the endothelial marker protein CD31 after SCI, suggesting damage to the blood-spinal cord barrier, and administration of melatonin increased the proportion of CD31-labeled vessels, suggesting that melatonin is effective in reducing the permeability of the blood-spinal cord barrier after SCI (Jing et al., 2017)