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Its active compounds enhance GLP-1 secretion from intestinal L-cells while increasing GLP-1 receptor sensitivity, helping improve glucose metabolism, reduce lipid accumulation, and support weight management through activation of important metabolic pathways like AMPK-signaling

GLP-1 drugs can significantly support weight loss and treat symptoms of type 2 diabetes by mimicking a hormone your body naturally uses to regulate your blood sugar and appetite

It operates in concert with two additional receptor pathways, amplifying effects that a single agonist could never achieve on its own

The TRIUMPH programme is evaluating retatrutide across multiple indications including chronic weight management, type 2 diabetes, knee osteoarthritis, moderate-to-severe obstructive sleep apnoea, chronic low back pain, cardiovascular and renal outcomes, and MASLD

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