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Additionally, MPP + has high affinity for noradrenergic and serotonergic uptake transporters [6,82], and its precursor, MPTP, has been mainly used in neuronal models with dopaminergic characteristics, such as the dopaminergic neuroblastoma cell line SH-SY5Y [83]

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The combination of a RAAS inhibitor with a steroidal MRA (spironolactone or eplerenone) may not be suitable, despite steroidal MRAs demonstrating efficacy in conditions such as HFrEF, resistant hypertension [58,59,60,61], hyperaldosteronism (spironolactone), as well as reducing proteinuria/albuminuria [60,61,62,63]

Direct light exposure and repeated freezing and thawing are described in the literature as factors that diminish peptide integrity