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Accumulating evidence indicates that dysregulated programmed cell death (PCD) is a pivotal mechanism driving dopaminergic neuronal loss and -syn pathology, thereby accelerating PD progression

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Capsules or softgels are convenient for daily use and travel

Persistent fatigue , tingling in the hands or feet, difficulty concentrating, or headaches could indicate B12 deficiency even with supplementation

Response: We note that in the CY 2026 OPPS/ASC proposed rule (90 FR 33775), we proposed to utilize the same file format requirementsthe QRDA standardapplied in the Hospital IQR, OQR, and Medicare Promoting Interoperability Programs (85 FR 58940, 86 FR 42262, and 80 FR 49706, respectively)

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