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Conversely, there is no evidence for accumulation of valproyl-CoA in brain tissue, suggesting that the effects of VPA in the CNS are independent of the formation of this metabolite [80]

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Depression in withdrawal may become protracted (see section on protracted symptoms) and if it does not lift within a few weeks and is unresponsive to simple reassurance and encouragement, it is worth seeking a medical opinion and possibly taking an antidepressant drug (see section on adjuvant medication)

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