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Moreover, advances in barrier penetration are poised to unlock applications in CNS disorders: bioinspired vectors harnessing endogenous transport mechanisms now demonstrate promise in crossing the BBB, opening new avenues for targeted degradation in neurodegenerative diseases [112, 296,297,298,299,300,301,302,303]

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For example, studies have identified inflammatory markers such as GlycA as being strongly associated with both the onset and persistence of depression, offering a promising direction for biomarker research in this domain [201]