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GHK-Cu's activity within the body is multi-functional, with the natural peptides production declining from approximately 200 ng/mL at age 20 to approximately 80 ng/mL by age 60

Consistently, NTAPP increased genes activating Wnt signaling pathway, which is involved in AMER3 17 , FRZB 18 , RSPO2 19 , LRP5L 20 , GRK5 21 , WNT11 22,23 and TMEM198 24 (Supplementary Figure 3d)

TAB2 and TAB3 activate the NF-B pathway through binding to polyubiquitin chains

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