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Approximately one third of patients with schizophrenia are considered to be treatment resistant [5], with the majority of these (2334%) failing to respond appreciably to dopamine-blocking antipsychotic medications from their first episode of psychosis (FEP) [6, 7]

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The molecular mechanisms underlying Pinealon's epigenetic effects involve sophisticated interactions with the chromatin remodeling machinery and epigenetic regulatory enzymes that control gene accessibility and transcriptional activity

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