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Under normal conditions, the tyrosine at position 18 (Tyr18) in the LIR region in FUNDC1 and the serine at position 13 (Ser13) close to the LIR is highly phosphorylated, at which time FUNDC1 has a low affinity for LC3 [62]

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Recognizing When Your Body Is Ready to Progress Signs you're ready for your next semaglutide dose increase include: nausea has resolved from your current level, you're tolerating regular meals without significant discomfort, weight loss is steady but not plateauing yet, and you've completed the full four-week period at your current dose

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