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The evidence indicates that intensive glucose control significantly prevents DPN in T1D but has limited effectiveness in T2D, reasons for this could be that T1D DPN is characterized by more severe structural degenerative changes, progressive axonal atrophy, and paranodal degenerative changes or maybe the difference could be caused owing to different susceptibility of nerve fibers to hyperglycemic damage between the two diabetes types

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Persistent or severe hypoglycemic episodes despite proper meal timing

The products were dialyzed against 0.5 M NaHCO 3 for 24 h, followed by dialysis against deionized water for over 24 h

Human obesity induces dysfunction and early senescence in adipose tissue-derived mesenchymal stromal/stem cells

[DOI] [PubMed] [Google Scholar] 14.Horowitz JF, Coppack SW, Paramore D, Cryer PE, Zhao G, Klein S