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However, high-dose oral therapy (1,0002,000 g daily) may be effective in some cases through passive diffusion, with appropriate monitoring

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These changes can disrupt the adaptive regulation of oxygenation in the retinal blood vessels, inhibit angiogenesis, and lead to further deterioration of the already compromised vascular endothelium in hyperglycemic conditions, potentially accelerating the progression of existing diabetic retinopathy [5,6,7,8]