In fact, an optimal ratio promotes and increases muscle energy metabolism by reducing the inhibitory effect exerted by the pyruvate dehydrogenase enzyme, which allows the conversion of pyruvate and lactate into acetyl CoA
Other biological processes, such as persistent viral reservoirs, chronic inflammation, autoimmunity, dysbiosis and microthrombotic phenomena, are also likely to contribute to the complex clinical manifestations of the syndrome
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Pediatr Endocrinol Rev 2 (Suppl 1): 8692 Tschop M et al
Tumours of the Rat , 2nd edition (Turusov V