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secondary IR cross-reactivity Key downstream pathways / PI3K-Akt-mTOR and RAS-MAPK-ERK IGF-1 DES comparison / DES is 6-aa truncated, 10x higher potency but even shorter half-life (~20-30 min) Regulatory status / Not FDA-approved for any indication

The effects of sleep deprivation and subsequent recovery on the central nervous system

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Saroj, Atul Biyani, Pratik Bagkar, Jayshree Kulkarni & Yogini Dixit (2021) Impact of a Gastrointestinal Stable Probiotic Supplement Bacillus coagulans LBSC on Human Gut Microbiome Modulation, Journal of Dietary Supplements, 18:6, 577-596, DOI: 10.1080/19390211.2020.1814931 Dina B

Most people notice reduced appetite within the first two weeks

Majority of patients read, check their phones or just sleep during this period